Refereed journal article or data article (A1)
Dual-capillary electroencapsulation of mesoporous silicon drug carrier particles for controlled oral drug delivery
List of Authors: Roine J, Murtomaa M, Myllys M, Salonen J
Publisher: ELSEVIER SCIENCE BV
Publication year: 2012
Journal: Journal of Electrostatics
Journal name in source: JOURNAL OF ELECTROSTATICS
Journal acronym: J ELECTROSTAT
Number in series: 5
Volume number: 70
Issue number: 5
Start page: 428
End page: 437
Number of pages: 10
ISSN: 0304-3886
eISSN: 0304-3886
DOI: http://dx.doi.org/10.1016/j.elstat.2012.06.003
URL: http://dx.doi.org/10.1016/j.elstat.2012.06.003
Abstract
The feasibility of electroencapsulation of mesoporous silicon (PSi) micro- and nanoparticles as a method to seal the PSI particles in mechanically processable solid units, and to facilitate time and site specific drug release from the pores of PSI particles, is of interest in the present work. Suitable microcapsules and micromatrix particles were produced in a single-step process using a setup with two electrospraying nozzles kept at high electric potentials of opposite polarities. The structures of the produced particles were analyzed by microscope and X-ray micro- and nanotomography imaging, and optimization of the electroencapsulation process production efficiency is discussed. (c) 2012 Elsevier B.V. All rights reserved.
The feasibility of electroencapsulation of mesoporous silicon (PSi) micro- and nanoparticles as a method to seal the PSI particles in mechanically processable solid units, and to facilitate time and site specific drug release from the pores of PSI particles, is of interest in the present work. Suitable microcapsules and micromatrix particles were produced in a single-step process using a setup with two electrospraying nozzles kept at high electric potentials of opposite polarities. The structures of the produced particles were analyzed by microscope and X-ray micro- and nanotomography imaging, and optimization of the electroencapsulation process production efficiency is discussed. (c) 2012 Elsevier B.V. All rights reserved.
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