Refereed review article in scientific journal (A2)
Advanced pancreatic cancer-how to choose an adequate treatment option
List of Authors: Korkeila E.
Publisher: WJG Press
Publication year: 2015
Journal: World Journal of Gastroenterology
Journal name in source: World Journal of Gastroenterology
Volume number: 21
Issue number: 38
Start page: 10709
End page: 10713
Number of pages: 5
ISSN: 2219-2840
DOI: http://dx.doi.org/10.3748/wjg.v21.i38.10709
The prognosis of pancreatic adenocarcinoma is poor, making it one of the leading causes of cancerrelated death. The 5-year overall survival rate remains below 5% and little progress is made during the past decade. Only about 10%-20% of patients are eligible for curative-intent surgery and the majority end up having recurring disease even after radical surgery and postoperative adjuvant chemotherapy. Chemotherapy in metastatic disease is palliative at best, aiming at disease and symptom control and prolongation of life. Treatment always causes side effects, the degree of which varies from patient to patient, depending on the patient's general condition, concomitant morbidities as well as on the chosen treatment modality. Why is pancreatic cancer so resistant to treatment? How to best help the patient to reach the set treatment goals?.