A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Does farm environment protect against type 1 diabetes mellitus?
Tekijät: Heikkinen SMM, Pitkaniemi JM, Kilpelainen ML, Koskenvuo MJ
Kustantaja: SAGE PUBLICATIONS LTD
Kustannuspaikka: LONDON; 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
Julkaisuvuosi: 2013
Journal: Diabetes and Vascular Disease Research
Tietokannassa oleva lehden nimi: Diabetes & Vascular Disease Research
Lehden akronyymi: Diabetes Vasc.Dis.Res.
Numero sarjassa: 4
Vuosikerta: 10
Numero: 4
Aloitussivu: 375
Lopetussivu: 377
Sivujen määrä: 3
ISSN: 1479-1641
DOI: https://doi.org/10.1177/1479164112474907
Tiivistelmä
Aims/Hypothesis: Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of childhood farm environment on the prevalence of type 1 diabetes mellitus in Finnish children and young adults. Methods: Data come from a questionnaire study carried out in 2007 (N = 5805). Prevalence of type 1 diabetes mellitus was analysed according to the type of the rural exposure below the age of 18 years. Associations were estimated and tested using Bayesian methods. Results: Consistent suggestive evidence of the inverse association of childhood's farm environment with the occurrence of type 1 diabetes mellitus was shown, even though conclusive results were not reached. Conclusion/Interpretation: Exposure to a broad variety of non-pathogenic environmental microorganisms during childhood might have a protective effect on type 1 diabetes mellitus. Results clearly suggest that further research is well grounded with larger samples.
Aims/Hypothesis: Hygiene hypothesis has been shown valid in respect of allergies and asthma but has not been, however, sufficiently studied in relation to type 1 diabetes mellitus. This study investigates the effect of childhood farm environment on the prevalence of type 1 diabetes mellitus in Finnish children and young adults. Methods: Data come from a questionnaire study carried out in 2007 (N = 5805). Prevalence of type 1 diabetes mellitus was analysed according to the type of the rural exposure below the age of 18 years. Associations were estimated and tested using Bayesian methods. Results: Consistent suggestive evidence of the inverse association of childhood's farm environment with the occurrence of type 1 diabetes mellitus was shown, even though conclusive results were not reached. Conclusion/Interpretation: Exposure to a broad variety of non-pathogenic environmental microorganisms during childhood might have a protective effect on type 1 diabetes mellitus. Results clearly suggest that further research is well grounded with larger samples.
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