A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Altered PCA3 and TMPRSS2-ERG expression in histologically benign regions of cancerous prostates: a systematic, quantitative mRNA analysis in five prostates
Tekijät: Vaananen RM, Ochoa NT, Bostrom PJ, Taimen P, Pettersson K
Kustantaja: BIOMED CENTRAL LTD
Julkaisuvuosi: 2015
Journal: BMC Urology
Tietokannassa oleva lehden nimi: BMC UROLOGY
Lehden akronyymi: BMC UROL
Artikkelin numero: ARTN 88
Vuosikerta: 15
Sivujen määrä: 8
ISSN: 1471-2490
eISSN: 1471-2490
DOI: https://doi.org/10.1186/s12894-015-0077-7
Conclusions: TMPRSS2-ERG expression was detected in carcinoma foci, regions next to them, and in samples not adjacent to carcinoma foci. Claimed as a cancer-associated phenomenon, this fusion gene measurement could, if validated with a larger cohort, be utilized as an addition to histological analysis to predict current or future cancer risk in men with negative biopsies. Molecular changes outside the carcinoma foci are also indicated for PCA3, as its expression was only moderately increased in the carcinoma regions.