A1 Refereed original research article in a scientific journal
ACID-CATALYZED DEPURINATION OF DIDEOXYRIBONUCLEOTIDES, TRIDEOXYRIBONUCLEOTIDES AND POLYDEOXYRIBONUCLEOTIDES - EFFECT OF MOLECULAR ENVIRONMENT ON THE CLEAVAGE OF ADENINE RESIDUE
Authors: HAKALA H, OIVANEN M, SALONIEMI E, GOUZAEV A, LONNBERG H
Publisher: JOHN WILEY & SONS LTD
Publication year: 1992
Journal:: Journal of Physical Organic Chemistry
Journal name in source: JOURNAL OF PHYSICAL ORGANIC CHEMISTRY
Journal acronym: J PHYS ORG CHEM
Volume: 5
Issue: 12
First page : 824
Last page: 828
Number of pages: 5
ISSN: 0894-3230
DOI: https://doi.org/10.1002/poc.610051208
Abstract
First-order rate constants for the acid-catalysed cleavage of adenine base from 2'-deoxyadenosine, its 3'- and 5'-monophosphates, various dinucleoside monophosphates, trinucleoside diphosphates and hexameric 2'-deoxyadenylic acid were measured by the method of initial velocity. The results obtained were compared with the effect that heteroassociation with caffeine has on the pre-equilibrium protonation and rate-limiting heterolysis of 2'-deoxyadenosine and its isosteric analogue, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)benzimidazole. The kinetics of the depurination of poly(dA-T), poly(dA) and a mixture of poly(dA) and poly(T) were determined, and the rate variations observed are discussed on the basis of the known structures of these polymers.
First-order rate constants for the acid-catalysed cleavage of adenine base from 2'-deoxyadenosine, its 3'- and 5'-monophosphates, various dinucleoside monophosphates, trinucleoside diphosphates and hexameric 2'-deoxyadenylic acid were measured by the method of initial velocity. The results obtained were compared with the effect that heteroassociation with caffeine has on the pre-equilibrium protonation and rate-limiting heterolysis of 2'-deoxyadenosine and its isosteric analogue, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)benzimidazole. The kinetics of the depurination of poly(dA-T), poly(dA) and a mixture of poly(dA) and poly(T) were determined, and the rate variations observed are discussed on the basis of the known structures of these polymers.
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