A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä
The "Hygiene hypothesis' and the sharp gradient in the incidence of autoimmune and allergic diseases between Russian Karelia and Finland
Tekijät: Kondrashova A, Seiskari T, Ilonen J, Knip M, Hyöty H
Julkaisuvuosi: 2013
Journal: APMIS
Tietokannassa oleva lehden nimi: Apmis
Lehden akronyymi: APMIS
Numero sarjassa: 6
Vuosikerta: 121
Numero: 6
Aloitussivu: 478
Lopetussivu: 493
Sivujen määrä: 16
ISSN: 0903-4641
DOI: https://doi.org/10.1111/apm.12023
Tiivistelmä
Autoimmune and allergic diseases have become a major health problem in the Western world during past decades. The hygiene hypothesis suggests that decreased microbial exposure in childhood leads to increasing prevalence of these diseases. This review summarizes epidemiological evidence and current immunological knowledge concerning the hygiene hypothesis. Recent results from Russian Karelia and Finland imply that environmental factors have greatly contributed to the increasing prevalence of immune-mediated disorders. Infections, or lack of them, may indeed be strongly involved in the development of both autoimmune and allergic diseases.
Autoimmune and allergic diseases have become a major health problem in the Western world during past decades. The hygiene hypothesis suggests that decreased microbial exposure in childhood leads to increasing prevalence of these diseases. This review summarizes epidemiological evidence and current immunological knowledge concerning the hygiene hypothesis. Recent results from Russian Karelia and Finland imply that environmental factors have greatly contributed to the increasing prevalence of immune-mediated disorders. Infections, or lack of them, may indeed be strongly involved in the development of both autoimmune and allergic diseases.
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