A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity
Tekijät: Rosberg Aylin, Merisaari Harri, Lewis John D, Hashempour Niloofar, Lukkarinen Minna, Rasmussen Jerod M, Scheinin Noora M, Karlsson Linnea, Karlsson Hasse, Tuulari Jetro J
Kustantaja: BioMed Central
Julkaisuvuosi: 2024
Journal: BMC Medicine
Tietokannassa oleva lehden nimi: BMC medicine
Lehden akronyymi: BMC Med
Artikkelin numero: 140
Vuosikerta: 22
Numero: 1
ISSN: 1741-7015
eISSN: 1741-7015
DOI: https://doi.org/10.1186/s12916-024-03340-z
Verkko-osoite: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-024-03340-z
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/387452004
Background: It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring's brain in a manner that confers future obesity risk. Here, we investigated how pre-pregnancy maternal weight status influences the reward-related striatal areas of the offspring's brain during in utero development.
Methods: We used diffusion tensor imaging to quantify the microstructure of the striatal brain regions of interest in neonates (N = 116 [66 males, 50 females], mean gestational weeks at birth [39.88], SD = 1.14; at scan [43.56], SD = 1.05). Linear regression was used to test the associations between maternal pre-pregnancy body mass index (BMI) and infant striatal mean diffusivity.
Results: High maternal pre-pregnancy BMI was associated with higher mean MD values in the infant's left caudate nucleus. Results remained unchanged after the adjustment for covariates.
Conclusions: In utero exposure to maternal adiposity might have a growth-impairing impact on the mean diffusivity of the infant's left caudate nucleus. Considering the involvement of the caudate nucleus in regulating eating behavior and food-related reward processing later in life, this finding calls for further investigations to define the prognostic relevance of early-life caudate nucleus development and weight trajectories of the offspring.
Ladattava julkaisu This is an electronic reprint of the original article. |