A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Beneficial effect of repeated participation in breast cancer screening upon survival
Tekijät: Duffy Stephen W, Yen Amy Ming-Fang Tabar Laszlo, Lin Abbie Ting-Yu, Chen Sam Li-Sheng, Hsu Chen-Yang, Dean Peter B, Smith Robert A, Chen Tony Hsiu-Hsi
Kustantaja: SAGE PUBLICATIONS LTD
Kustannuspaikka: London
Julkaisuvuosi: 2023
Journal: Journal of Medical Screening
Tietokannassa oleva lehden nimi: JOURNAL OF MEDICAL SCREENING
Lehden akronyymi: J MED SCREEN
Sivujen määrä: 5
ISSN: 0969-1413
eISSN: 1475-5793
DOI: https://doi.org/10.1177/09691413231186686
Verkko-osoite: https://doi.org/10.1177/09691413231186686
Rinnakkaistallenteen osoite: https://research.utu.fi/converis/portal/detail/Publication/386795091
Objectives: The benefit of mammography screening in reducing population mortality from breast cancer is well established. In this paper, we estimate the effect of repeated participation at scheduled screens on case survival.
Methods: We analysed incidence and survival data on 37,079 women from nine Swedish counties who had at least one to five invitation(s) to screening prior to diagnosis, and were diagnosed with breast cancer between 1992 and 2016. Of these, 4564 subsequently died of breast cancer. We estimated the association of survival with participation in up to the most recent five screens before diagnosis. We used proportional hazards regression to estimate the effect on survival of the number of scheduled screens in which subjects participated prior to the diagnosis of breast cancer.
Results: There was successively better survival with an increasing number of screens in which the subject participated. For a woman with five previous screening invitations who participated in all five, the hazard ratio was 0.28 (95% confidence interval (CI) 0.25-0.33, p < 0.0001) compared to a woman attending none (86.9% vs 68.9% 20-year survival). Following a conservative adjustment for potential self-selection factors, the hazard ratio was 0.34 (95% CI 0.26-0.43, p < 0.0001), an approximate three-fold reduction in the hazard of dying from breast cancer.
Conclusion: For those women who develop breast cancer, regular prior participation in mammography screening confers significantly better survival.
Ladattava julkaisu This is an electronic reprint of the original article. |