A1 Refereed original research article in a scientific journal

Mammary-Derived Growth Inhibitor Alters Traffic of EGFR and Induces a Novel Form of Cetuximab Resistance



Authors: Nevo J, Mattila E, Pellinen T, Yamamoto DL, Sara H, Iljin K, Kallioniemi O, Bono P, Heikkila P, Joensuu H, Warri A, Ivaska J

Publisher: AMER ASSOC CANCER RESEARCH

Publication year: 2009

Journal: Clinical Cancer Research

Journal name in source: CLINICAL CANCER RESEARCH

Journal acronym: CLIN CANCER RES

Volume: 15

Issue: 21

First page : 6570

Last page: 6581

Number of pages: 12

ISSN: 1078-0432

DOI: https://doi.org/10.1158/1078-0432.CCR-09-0773


Abstract
Conclusions: MDGI-driven inherent desensitization of cancer cells is a novel molecular mechanism for resistance to the anti-EGFR antibody therapy, and MDGI may be a biomarker for responsiveness to anti-EGFR antibody therapy. (Clin Cancer Res 2009;15(21):6570-81)



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