A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä

Contralateral non-operated nerve to transected rat sciatic nerve shows increased expression of IL-1beta, TGF-beta1, TNF-alpha, and IL-10.




TekijätRuohonen S, Jagodi M, Khademi M, Taskinen HS, Ojala P, Olsson T, Röyttä M

Julkaisuvuosi2002

Lehti:Journal of Neuroimmunology

Tietokannassa oleva lehden nimiJournal of neuroimmunology

Lehden akronyymiJ Neuroimmunol

Vuosikerta132

Numero1-2

Aloitussivu11

Lopetussivu7

Sivujen määrä-3

ISSN0165-5728

DOIhttps://doi.org/10.1016/S0165-5728(02)00281-3


Tiivistelmä

Recent reports indicate that after a peripheral nerve injury, the uninjured contralateral nerve is also affected. Because cytokines play an important role in the peripheral nerve injury, we studied the expression of five different mRNAs (interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), interleukin-10 (IL-10), transforming growth factor-beta1 (TGF-beta1) and interleukin-4 (IL-4)) in the contralateral, non-operated, left sciatic nerve when the right rat sciatic nerve was transected. This study extended up to 42 days after the transection. No IL-4 expression was noted. During the first 3 days, high expression of the other studied cytokines was noted in the endoneurium. At day 7, the expression diminished to the control levels. After this, a cyclic expression pattern appeared, which was most pronounced in the endoneurium at 35 days. We also show that the expression pattern in the endoneurium is different from that in the surrounding epi- and perineurium. Also, our present study shows clearly that contralateral nerves are poor controls after injury.




Last updated on 2025-14-10 at 09:35