A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Reshaping the Gut Microbiota at an Early Age: Functional Impact on Obesity Risk?
Tekijät: Luoto R, Collado MC, Salminen S, Isolauri E
Kustantaja: KARGER
Julkaisuvuosi: 2013
Journal: Annals of Nutrition and Metabolism
Tietokannassa oleva lehden nimi: ANNALS OF NUTRITION AND METABOLISM
Lehden akronyymi: ANN NUTR METAB
Vuosikerta: 63
Aloitussivu: 17
Lopetussivu: 26
Sivujen määrä: 10
ISSN: 0250-6807
DOI: https://doi.org/10.1159/000354896
Tiivistelmä
Overweight and obesity can currently be considered a major threat to human health and well-being. Recent scientific advances point to an aberrant compositional development of the gut microbiota and low-grade inflammation as contributing factors, in conjunction with excessive energy intake. A high-fat/energy diet alters the gut microbiota composition, which reciprocally engenders excessive energy harvesting and storage. Further, microbial imbalance increases gut permeability, leading to metabolic endotoxemia, inflammation and insulin resistance. Local intestinal immunologic homeostasis is achieved by tolerogenic immune responses to microbial antigens. In the context of amelioration of insulin sensitivity and decreased adiposity, the potential of gut microbiota modulation with specific probiotics and prebiotics lies in the normalization of aberrant microbiota, improved gut barrier function and creation of an anti-inflammatory milieu. This would suggest a role for probiotic/prebiotic interventions in the search for preventive and therapeutic applications in weight management. (C) 2013 S. Karger AG, Basel
Overweight and obesity can currently be considered a major threat to human health and well-being. Recent scientific advances point to an aberrant compositional development of the gut microbiota and low-grade inflammation as contributing factors, in conjunction with excessive energy intake. A high-fat/energy diet alters the gut microbiota composition, which reciprocally engenders excessive energy harvesting and storage. Further, microbial imbalance increases gut permeability, leading to metabolic endotoxemia, inflammation and insulin resistance. Local intestinal immunologic homeostasis is achieved by tolerogenic immune responses to microbial antigens. In the context of amelioration of insulin sensitivity and decreased adiposity, the potential of gut microbiota modulation with specific probiotics and prebiotics lies in the normalization of aberrant microbiota, improved gut barrier function and creation of an anti-inflammatory milieu. This would suggest a role for probiotic/prebiotic interventions in the search for preventive and therapeutic applications in weight management. (C) 2013 S. Karger AG, Basel
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