A1 Journal article – refereed

Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability




List of Authors: Guillaume Jacquemet, Aki Stubb, Rafael Saup, Mitro Miihkinen, Elena Kremneva, Hellyeh Hamidi, Johanna Ivaska

Publication year: 2019

Journal: Current Biology

Journal name in source: Current biology : CB

Journal acronym: Curr Biol

Volume number: 29

Issue number: 2

Number of pages: 22

ISSN: 0960-9822

eISSN: 1879-0445

DOI: http://dx.doi.org/10.1016/j.cub.2018.11.053


Abstract
in filopodia tips, predicts critical roles for PIs in regulating filopodia ultra-structure and function. Our mapping further reveals that filopodia adhesions consist of a unique set of proteins, the filopodome, that are distinct from classical nascent adhesions, focal adhesions, and fibrillar adhesions. Using live imaging, we observe that filopodia adhesions can give rise to nascent adhesions, which, in turn, form focal adhesions. We demonstrate that p130Cas (BCAR1) is recruited to filopodia tips via its C-terminal Cas family homology domain (CCHD) and acts as a mechanosensitive regulator of filopodia stability. Finally, we demonstrate that our map based on myosin-X-induced filopodia can be translated to endogenous filopodia and fascin- and IRSp53-mediated filopodia.

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Last updated on 2021-24-06 at 09:09