A1 Refereed original research article in a scientific journal
Natriuretic peptides in hormonal regulation of hypoxia responses
Authors: Arjamaa O, Nikinmaa M
Publisher: AMER PHYSIOLOGICAL SOC
Publication year: 2009
Journal: AJP - Regulatory, Integrative and Comparative Physiology
Journal name in source: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
Journal acronym: AM J PHYSIOL-REG I
Volume: 296
Issue: 2
First page : R257
Last page: R264
Number of pages: 8
ISSN: 0363-6119
DOI: https://doi.org/10.1152/ajpregu.90696.2008
Abstract
Arjamaa O, Nikinmaa M. Natriuretic peptides in hormonal regulation of hypoxia responses. Am J Physiol Regul Integr Comp Physiol 295: R257-R264, 2009. First published November 12, 2008; doi: 10.1152/ajpregu.90696.2008.-The possibility that natriuretic peptides' effects are important in hypoxia responses of vertebrates is reviewed. Both the transcription and release of natriuretic peptides are affected by oxygen tension. Furthermore, many of the effects observed in hypoxia, such as diuresis and a reduction of plasma volume, are also caused by treatment of the animal with natriuretic peptides. Also, several clinical observations about changes in natriuretic peptide levels in, e. g., sleep apnea and cyanotic congenital heart disease, are consistent with the idea that hypoxia is involved in the etiology of conditions, in which natriuretic peptide levels increase. Virtually all published information on the relationship between oxygen and natriuretic peptides is based on human studies. Because hypoxic conditions are more common in aquatic than terrestrial environments, future studies about the possible role of natriuretic peptides in hypoxia, as well as the role of hypoxia in the evolution of natriuretic peptides, including the different subtypes, should increasingly involve also aquatic organisms.
Arjamaa O, Nikinmaa M. Natriuretic peptides in hormonal regulation of hypoxia responses. Am J Physiol Regul Integr Comp Physiol 295: R257-R264, 2009. First published November 12, 2008; doi: 10.1152/ajpregu.90696.2008.-The possibility that natriuretic peptides' effects are important in hypoxia responses of vertebrates is reviewed. Both the transcription and release of natriuretic peptides are affected by oxygen tension. Furthermore, many of the effects observed in hypoxia, such as diuresis and a reduction of plasma volume, are also caused by treatment of the animal with natriuretic peptides. Also, several clinical observations about changes in natriuretic peptide levels in, e. g., sleep apnea and cyanotic congenital heart disease, are consistent with the idea that hypoxia is involved in the etiology of conditions, in which natriuretic peptide levels increase. Virtually all published information on the relationship between oxygen and natriuretic peptides is based on human studies. Because hypoxic conditions are more common in aquatic than terrestrial environments, future studies about the possible role of natriuretic peptides in hypoxia, as well as the role of hypoxia in the evolution of natriuretic peptides, including the different subtypes, should increasingly involve also aquatic organisms.
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