Analyses of Gingival Adhesion Molecules in Periodontitis: Theoretical In Silico, Comparative In Vivo, and Explanatory In Vitro Models

: Gursoy UK, Zeidan-Chulia F, Yilmaz D, Ouml;zdemir V, Maki-Petays J, de Oliveira BHN, Firatli Y, Guncu GN, Caglayan F, Kononen E

Publisher: AMER ACAD PERIODONTOLOGY

: 2016

Journal of Periodontology

: JOURNAL OF PERIODONTOLOGY

: J PERIODONTOL

: 87

: 2

: 193

: 202

: 10

: 0022-3492

DOI: https://doi.org/10.1902/jop.2015.150361

Conclusions: Gene expression of gingival adhesion molecules in periodontitis is regulated by leukocyte transmigration, whereas the neutrophilic antimicrobial peptide HNP-1 is noted as a putative regulator of epithelial adhesion molecules. These observations contribute to the key mechanisms by which future biomarkers might be developed for periodontitis.

Biological markers, cell adhesion, defensins, gene expression, neutrophils, protein interaction maps