A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Plant stanol esters in low-fat yogurt reduces total and low-density lipoprotein cholesterol and low-density lipoprotein oxidation in normocholesterolemic and mildly hypercholesterolemic subjects
Tekijät: Hyun YJ, Kim OY, Kang JB, Lee JH, Jang Y, Liponkoski L, Salo P
Kustantaja: PERGAMON-ELSEVIER SCIENCE LTD
Julkaisuvuosi: 2005
Journal: Nutrition Research
Tietokannassa oleva lehden nimi: NUTRITION RESEARCH
Lehden akronyymi: NUTR RES
Vuosikerta: 25
Numero: 8
Aloitussivu: 743
Lopetussivu: 753
Sivujen määrä: 11
ISSN: 0271-5317
DOI: https://doi.org/10.1016/j.nutres.2005.08.004
Tiivistelmä
We examined the effects of plant stanol ester contained in low-fat yogurt on serum lipids and low-density lipoprotein (LDL) oxidation in Korean young adults with normocholesterolemia and mild hypercholesterolemia. After screening tests (fasting total cholesterol, 174 to 251 mg/dL; and fasting triacylglycerols, < 266 mg/dL), 51 subjects (28.7 +/- 0.7 years, 22.6 +/- 0.4 kg/m(2)) were included in the study and randomly assigned to a group receiving yogurt with either a plant stanol ester or a placebo. Four weeks' intake of plant stanol (2 g/d) as its fatty acid ester lowered total and LDL cholesterol levels by almost 6% and 10%, respectively, without affecting high-density lipoprotein cholesterol and triacylglycerol concentrations. Plasma oxidized LDL was also reduced by 5.4% in the test group. Serum beta-carotene and retinol were unchanged in both groups; however, lipid-corrected serum alpha-tocopherol was significantly increased in the test group (P < .05) We conclude that plant stanol ester contained in low-fat yogurt may be effective in reducing total and LDL cholesterol and oxidized LDL level in a habitual diet without restriction of fat and cholesterol intake. Foods containing plant sterols or stanols might be a useful tool for normocholesterolemic and mildly hypercholesterolemic individuals to prevent more severe hypercholesterolemia and cardiovascular disease. (c) 2005 Elsevier Inc. All rights reserved.
We examined the effects of plant stanol ester contained in low-fat yogurt on serum lipids and low-density lipoprotein (LDL) oxidation in Korean young adults with normocholesterolemia and mild hypercholesterolemia. After screening tests (fasting total cholesterol, 174 to 251 mg/dL; and fasting triacylglycerols, < 266 mg/dL), 51 subjects (28.7 +/- 0.7 years, 22.6 +/- 0.4 kg/m(2)) were included in the study and randomly assigned to a group receiving yogurt with either a plant stanol ester or a placebo. Four weeks' intake of plant stanol (2 g/d) as its fatty acid ester lowered total and LDL cholesterol levels by almost 6% and 10%, respectively, without affecting high-density lipoprotein cholesterol and triacylglycerol concentrations. Plasma oxidized LDL was also reduced by 5.4% in the test group. Serum beta-carotene and retinol were unchanged in both groups; however, lipid-corrected serum alpha-tocopherol was significantly increased in the test group (P < .05) We conclude that plant stanol ester contained in low-fat yogurt may be effective in reducing total and LDL cholesterol and oxidized LDL level in a habitual diet without restriction of fat and cholesterol intake. Foods containing plant sterols or stanols might be a useful tool for normocholesterolemic and mildly hypercholesterolemic individuals to prevent more severe hypercholesterolemia and cardiovascular disease. (c) 2005 Elsevier Inc. All rights reserved.
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