A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Effects of low-fat hard cheese enriched with plant stanol esters on serum lipids and apolipoprotein B in mildly hypercholesterolaemic subjects
Tekijät: Jauhiainen T, Salo P, Niittynen L, Poussa T, Korpela R
Kustantaja: NATURE PUBLISHING GROUP
Julkaisuvuosi: 2006
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF CLINICAL NUTRITION
Lehden akronyymi: EUR J CLIN NUTR
Vuosikerta: 60
Numero: 11
Aloitussivu: 1253
Lopetussivu: 1257
Sivujen määrä: 5
ISSN: 0954-3007
DOI: https://doi.org/10.1038/sj.ejcn.1602445
Tiivistelmä
Objective: To investigate the cholesterol-lowering effects of a low-fat cheese enriched with plant stanol esters in mildly hypercholesterolaemic subjects, as part of their normal diet.Design: A randomized double-blind parallel-group study.Setting: Valio Ltd, Helsinki.Subjects: Sixty-seven mildly hypercholesterolaemic volunteers (24 men, 43 women) participated in the study, which all of them completed.Interventions: The subjects were randomly assigned to the plant stanol ester group or the control group. During the 5-week intervention, the subjects in the stanol group consumed a cheese enriched with 2 g of plant stanols per day, and the subjects in the control group, a control cheese with no plant stanols.Results: In the stanol ester group, as compared to the control group, both serum total and low-density lipoprotein (LDL) cholesterol decreased significantly, that is, by 5.8% (-0.32 mmol/ l, 95% CI -0.50 to -0.15 mmol/ l, P < 0.001) and 10.3% (-0.36 mmol/ l, 95% CI -0.53 to -0.18 mmol/ l, P < 0.001), respectively. There were no significant changes in high-density lipoprotein cholesterol (HDL), triglycerides or apolipoprotein B concentrations between the groups.Conclusion: Cheese enriched with 2 g of plant stanol in the form of fatty acid esters decreases serum total and LDL cholesterol significantly.
Objective: To investigate the cholesterol-lowering effects of a low-fat cheese enriched with plant stanol esters in mildly hypercholesterolaemic subjects, as part of their normal diet.Design: A randomized double-blind parallel-group study.Setting: Valio Ltd, Helsinki.Subjects: Sixty-seven mildly hypercholesterolaemic volunteers (24 men, 43 women) participated in the study, which all of them completed.Interventions: The subjects were randomly assigned to the plant stanol ester group or the control group. During the 5-week intervention, the subjects in the stanol group consumed a cheese enriched with 2 g of plant stanols per day, and the subjects in the control group, a control cheese with no plant stanols.Results: In the stanol ester group, as compared to the control group, both serum total and low-density lipoprotein (LDL) cholesterol decreased significantly, that is, by 5.8% (-0.32 mmol/ l, 95% CI -0.50 to -0.15 mmol/ l, P < 0.001) and 10.3% (-0.36 mmol/ l, 95% CI -0.53 to -0.18 mmol/ l, P < 0.001), respectively. There were no significant changes in high-density lipoprotein cholesterol (HDL), triglycerides or apolipoprotein B concentrations between the groups.Conclusion: Cheese enriched with 2 g of plant stanol in the form of fatty acid esters decreases serum total and LDL cholesterol significantly.
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