A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Vasoactive mediators and retinopathy during type 1 diabetic pregnancy
Tekijät: Loukovaara S, Immonen IJ, Yandle TG, Nicholls G, Hiilesmaa VK, Kaaja RJ
Julkaisuvuosi: 2005
Journal: Acta Ophthalmologica Scandinavica
Tietokannassa oleva lehden nimi: Acta ophthalmologica Scandinavica
Lehden akronyymi: Acta Ophthalmol Scand
Vuosikerta: 83
Numero: 1
Aloitussivu: 57
Lopetussivu: 62
Sivujen määrä: 6
ISSN: 1395-3907
DOI: https://doi.org/10.1111/j.1600-0420.2005.00384.x
Tiivistelmä
To evaluate the role of various vasoactive hormones in the evolution of diabetic retinopathy during pregnancy and postpartum.\nRetinopathy was graded from fundus photographs of 45 pregnant women with type 1 diabetes and seven pregnant women without diabetes in a prospective study. Markers of renin-angiotensin-system (RAS), plasma renin activity (PRA), angiotensin II (AngII), aldosterone, natriuretic peptides (ANP, BNP, CNP) and adreonomedullin (AM) were measured during the first and third trimesters and at 3 months postpartum. The women with diabetes were grouped by progression of retinopathy during pregnancy and postpartum.\nLevels of PRA (p = 0.001) and ANP (p = 0.03) were significantly lower in diabetes than in non-diabetes subjects throughout pregnancy and postpartum. No significant differences appeared in levels of AngII, aldosterone, AM, BNP or CNP between the two groups. In multivariate logistic regression analyses with retinopathy progression by the third trimester as the dependent variable, only duration of diabetes qualified in the model (p = 0.027, R = 0.227, Exp(B) = 1.28).\nDiabetic pregnancy is associated with lower levels of PRA and ANP compared to non-diabetic pregnancy. Lowered RAS activity may contribute to the hyperdynamic blood flow and progression of DR during diabetic pregnancy. Within the power of this study no clear associations between the vasoactive hormones and progression of retinopathy could be detected.\nPURPOSE\nMETHODS\nRESULTS\nCONCLUSIONS
To evaluate the role of various vasoactive hormones in the evolution of diabetic retinopathy during pregnancy and postpartum.\nRetinopathy was graded from fundus photographs of 45 pregnant women with type 1 diabetes and seven pregnant women without diabetes in a prospective study. Markers of renin-angiotensin-system (RAS), plasma renin activity (PRA), angiotensin II (AngII), aldosterone, natriuretic peptides (ANP, BNP, CNP) and adreonomedullin (AM) were measured during the first and third trimesters and at 3 months postpartum. The women with diabetes were grouped by progression of retinopathy during pregnancy and postpartum.\nLevels of PRA (p = 0.001) and ANP (p = 0.03) were significantly lower in diabetes than in non-diabetes subjects throughout pregnancy and postpartum. No significant differences appeared in levels of AngII, aldosterone, AM, BNP or CNP between the two groups. In multivariate logistic regression analyses with retinopathy progression by the third trimester as the dependent variable, only duration of diabetes qualified in the model (p = 0.027, R = 0.227, Exp(B) = 1.28).\nDiabetic pregnancy is associated with lower levels of PRA and ANP compared to non-diabetic pregnancy. Lowered RAS activity may contribute to the hyperdynamic blood flow and progression of DR during diabetic pregnancy. Within the power of this study no clear associations between the vasoactive hormones and progression of retinopathy could be detected.\nPURPOSE\nMETHODS\nRESULTS\nCONCLUSIONS
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