A1 Refereed original research article in a scientific journal
Serum activin A and inhibin A elevated in pre-eclampsia: no relation to insulin sensitivity
Authors: Laivuori H, Kaaja R, Turpeinen U, Stenman UH, Ylikorkala O
Publication year: 1999
Journal: British journal of obstetrics and gynaecology
Journal name in source: British journal of obstetrics and gynaecology
Journal acronym: Br J Obstet Gynaecol
Volume: 106
Issue: 12
First page : 1298
Last page: 303
Number of pages: 6
ISSN: 0306-5456
DOI: https://doi.org/10.1111/j.1471-0528.1999.tb08185.x
Abstract
To assess the possible role of serum levels of activin A, inhibin A and pro-alpha inhibin (pro-alphaC) in insulin sensitivity in pre-eclampsia.\nA prospective study.\nHelsinki University Central Hospital.\nTwenty-two nulliparous women with proteinuric pre-eclampsia and 16 healthy nulliparous controls in the third trimester of pregnancy.\nSerum samples were collected before and after intravenous injection of glucose (0.3 g/kg) and insulin (0.03 IU/kg) (the minimal model for testing insulin sensitivity), and were assayed for activin A, inhibin A and pro-alphaC.\nComparison of the levels of activin A, inhibin A and pro-alphaC between pre-eclamptic and healthy pregnant women, and the association of these proteins with insulin sensitivity.\nIn pre-eclampsia elevated levels of activin A (139%, P = 0.0001), inhibin A (39%, P = 0.003), and pro-alphaC (92%, P = 0.0008) were observed. The amount of proteinuria (0.3-10.5 g/day) correlated positively with serum concentrations of activin A (P = 0.01) and inhibin A (P = 0.02). These glycoproteins were not associated with insulin sensitivity either in women with pre-eclampsia or controls. A 2.9-fold rise in blood glucose and a 52.5-fold rise in insulin during testing using the minimal model were not accompanied by any significant changes in activin A, inhibin A, and pro-alphaC.\nActivin A, inhibin A, and pro-alphaC are elevated in pre-eclampsia but do not appear to relate to the insulin sensitivity in pre-eclamptic or normal pregnancies.\nOBJECTIVE\nDESIGN\nSETTING\nPARTICIPANTS\nMETHODS\nMAIN OUTCOME MEASURES\nRESULTS\nCONCLUSION
To assess the possible role of serum levels of activin A, inhibin A and pro-alpha inhibin (pro-alphaC) in insulin sensitivity in pre-eclampsia.\nA prospective study.\nHelsinki University Central Hospital.\nTwenty-two nulliparous women with proteinuric pre-eclampsia and 16 healthy nulliparous controls in the third trimester of pregnancy.\nSerum samples were collected before and after intravenous injection of glucose (0.3 g/kg) and insulin (0.03 IU/kg) (the minimal model for testing insulin sensitivity), and were assayed for activin A, inhibin A and pro-alphaC.\nComparison of the levels of activin A, inhibin A and pro-alphaC between pre-eclamptic and healthy pregnant women, and the association of these proteins with insulin sensitivity.\nIn pre-eclampsia elevated levels of activin A (139%, P = 0.0001), inhibin A (39%, P = 0.003), and pro-alphaC (92%, P = 0.0008) were observed. The amount of proteinuria (0.3-10.5 g/day) correlated positively with serum concentrations of activin A (P = 0.01) and inhibin A (P = 0.02). These glycoproteins were not associated with insulin sensitivity either in women with pre-eclampsia or controls. A 2.9-fold rise in blood glucose and a 52.5-fold rise in insulin during testing using the minimal model were not accompanied by any significant changes in activin A, inhibin A, and pro-alphaC.\nActivin A, inhibin A, and pro-alphaC are elevated in pre-eclampsia but do not appear to relate to the insulin sensitivity in pre-eclamptic or normal pregnancies.\nOBJECTIVE\nDESIGN\nSETTING\nPARTICIPANTS\nMETHODS\nMAIN OUTCOME MEASURES\nRESULTS\nCONCLUSION
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