Maternal antihypertensive therapy with beta-blockers associated with poor outcome in very-low birthweight infants



: Kaaja R, Hiilesmaa V, Holma K, Järvenpää AL

: 1992

: International Journal of Gynecology and Obstetrics

: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics

: Int J Gynaecol Obstet

: 38

: 3

: 195

: 9

: 5

: 0020-7292

DOI: https://doi.org/10.1016/0020-7292(82)90128-X


The progress of 36 very-low birthweight (less than or equal to 1500 g) infants born to mothers with pregnancy-induced hypertonia or pre-eclampsia was studied. During the first year of life, 7 out of 19 infants died when the mothers' antihypertensive regimen included beta-blockers. Four of the deaths occurred within 15 days. There were no deaths in 16 infants whose mothers were treated with other antihypertensive treatment (P = 0.006). These results suggest that maternal beta-blocker therapy may have adverse effects on the very-low birthweight infants.



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