A1 Refereed original research article in a scientific journal
Maternal antihypertensive therapy with beta-blockers associated with poor outcome in very-low birthweight infants
Authors: Kaaja R, Hiilesmaa V, Holma K, Järvenpää AL
Publication year: 1992
Journal: International Journal of Gynecology and Obstetrics
Journal name in source: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
Journal acronym: Int J Gynaecol Obstet
Volume: 38
Issue: 3
First page : 195
Last page: 9
Number of pages: 5
ISSN: 0020-7292
DOI: https://doi.org/10.1016/0020-7292(82)90128-X
Abstract
The progress of 36 very-low birthweight (less than or equal to 1500 g) infants born to mothers with pregnancy-induced hypertonia or pre-eclampsia was studied. During the first year of life, 7 out of 19 infants died when the mothers' antihypertensive regimen included beta-blockers. Four of the deaths occurred within 15 days. There were no deaths in 16 infants whose mothers were treated with other antihypertensive treatment (P = 0.006). These results suggest that maternal beta-blocker therapy may have adverse effects on the very-low birthweight infants.
The progress of 36 very-low birthweight (less than or equal to 1500 g) infants born to mothers with pregnancy-induced hypertonia or pre-eclampsia was studied. During the first year of life, 7 out of 19 infants died when the mothers' antihypertensive regimen included beta-blockers. Four of the deaths occurred within 15 days. There were no deaths in 16 infants whose mothers were treated with other antihypertensive treatment (P = 0.006). These results suggest that maternal beta-blocker therapy may have adverse effects on the very-low birthweight infants.
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