A1 Refereed original research article in a scientific journal
Leucopenia associated with beta-lactam antibiotic therapy
Authors: Kaaja R, Valtonen VV
Publication year: 1984
Journal: Acta Mecica Scandinavica
Journal name in source: Acta medica Scandinavica
Journal acronym: Acta Med Scand
Volume: 216
Issue: 5
First page : 531
Last page: 4
Number of pages: 4
ISSN: 0001-6101
Abstract
Two cases of penicillin-induced and one case of cephalosporin-induced leucopenia are described. This unusual complication of widely used beta-lactam antibiotics can occur when these antibiotics are administered parenterally in high doses for prolonged periods (14 days or more). The close monitoring of the white cell count is important when treating patients with high doses of beta-lactam antibiotics for prolonged periods. We would like to emphasize that when penicillin- or cephalosporin-induced leucopenia is suspected, continuation with another beta-lactam antibiotic may be dangerous.
Two cases of penicillin-induced and one case of cephalosporin-induced leucopenia are described. This unusual complication of widely used beta-lactam antibiotics can occur when these antibiotics are administered parenterally in high doses for prolonged periods (14 days or more). The close monitoring of the white cell count is important when treating patients with high doses of beta-lactam antibiotics for prolonged periods. We would like to emphasize that when penicillin- or cephalosporin-induced leucopenia is suspected, continuation with another beta-lactam antibiotic may be dangerous.
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