A1 Refereed original research article in a scientific journal
Serum cytokine levels differ according to major cardiovascular risk factors in patients with lower limb atherosclerosis
Authors: Jalkanen J., Hollmén M., Maksimow M., Jalkanen S., Hakovirta H.
Publisher: Academic Press
Publication year: 2019
Journal: Cytokine
Journal name in source: Cytokine
Volume: 114
First page : 74
Last page: 80
Number of pages: 7
ISSN: 1043-4666
eISSN: 1096-0023
DOI: https://doi.org/10.1016/j.cyto.2018.11.001
Different cardiovascular risk factors present a heterogenic
manifestation of lower limb atherosclerosis. The molecular mechanisms
behind this phenomenon remain unknown. We aimed to clarify this
phenomenon by studying the association of major cardiovascular risk
factors with the profile of serum cytokines in 226 consecutive patients
with lower limb atherosclerosis treated at a department of Vascular
Surgery during a one-year enrollment period. Increasing age
independently associated with higher levels of IFN-γ inducible factors
MIG, CTACK and IP-10 (P < 0.001 for all). Patients with chronic kidney disease had higher serum levels of MIF, IL-16 and SCF (P = 0.001 or less for all). Smoking and hypertension associated with IL-17 (P = 0.037
and 0.015, respectively). In addition, smoking associated with growth
factors known to induce myeloid progenitor cell proliferation: GM-CSF (P = 0.035), PDGF (P = 0.024), bFGF (P = 0.026), and HGF (P = 0.030). Dyslipidemia also associated with myeloproliferative factors: MIB-1α (P = 0.005) and PDGF (P = 0.01). Type II diabetes associated with Th2 mediated inflammation: IL-5 (P < 0.001), IL-7 (P = 0.004) and IL-13 (P = 0.015).
Major cardiovascular risk factors are associated with different
circulating cytokines implicating different immunological pathology.
