A1 Refereed original research article in a scientific journal
Homing-associated molecules CD73 and VAP-1 as targets to prevent harmful inflammations and cancer spread
Authors: Salmi M, Jalkanen S
Publisher: ELSEVIER SCIENCE BV
Publication year: 2011
Journal: FEBS Letters
Journal name in source: FEBS LETTERS
Journal acronym: FEBS LETT
Number in series: 11
Volume: 585
Issue: 11
First page : 1543
Last page: 1550
Number of pages: 8
ISSN: 0014-5793
DOI: https://doi.org/10.1016/j.febslet.2011.04.033
Abstract
Homing-associated molecules are of fundamental importance for proper functioning of our immune system as they direct the cells to sites of inflammation to create an immune response. However, they are also responsible for harmful cell trafficking, which takes place in acute and chronic inflammations as well as in tumor progression and metastatic spread of cancer. Therefore, these molecules are potential targets for developing drugs to prevent harmful inflammation and metastases of cancer. In this review, we will discuss about the most recent advances in studies elucidating the role of two homing-associated ecto-enzymes in physiological and pathological cell trafficking and their use as drug targets. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Homing-associated molecules are of fundamental importance for proper functioning of our immune system as they direct the cells to sites of inflammation to create an immune response. However, they are also responsible for harmful cell trafficking, which takes place in acute and chronic inflammations as well as in tumor progression and metastatic spread of cancer. Therefore, these molecules are potential targets for developing drugs to prevent harmful inflammation and metastases of cancer. In this review, we will discuss about the most recent advances in studies elucidating the role of two homing-associated ecto-enzymes in physiological and pathological cell trafficking and their use as drug targets. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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