A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Neonatal Outcomes of Very Preterm or Very Low Birth Weight Triplets
Tekijät: Prakesh S. Shah, Satoshi Kusuda, Stellan Håkansson, Brian Reichman, Kei Lui, Liisa Lehtonen, Neena Modi, Maximo Vento, Mark Adams, Franca Rusconi, Mikael Norman, Brian A. Darlow, Abhay Lodha, Junmin Yang, Dirk Bassler, Kjell K. Helenius, Tetsuya Isayama, Shoo K. Lee; on behalf of the International Network for Evaluation of Outcomes (iNEO) in Neonates Investigators
Kustantaja: American Academy of Pediatrics
Julkaisuvuosi: 2018
Journal: Pediatrics
Tietokannassa oleva lehden nimi: PEDIATRICS
Lehden akronyymi: PEDIATRICS
Artikkelin numero: ARTN e20181938
Vuosikerta: 142
Numero: 6
Sivujen määrä: 9
ISSN: 0031-4005
DOI: https://doi.org/10.1542/peds.2018-1938
OBJECTIVES: To compare the neonatal outcomes of very preterm triplets with those of matched singletons using a large international cohort.METHODS: A retrospective matched-cohort study of preterm triplets and singletons born between 2007 and 2013 in the International Network for Evaluation of Outcomes in neonates database countries and matched by gestational age, sex, and country of birth was conducted. The primary outcome was a composite of mortality or severe neonatal morbidity (severe neurologic injury, treated retinopathy of prematurity, and bronchopulmonary dysplasia). Unadjusted and adjusted odds ratios with 95% confidence intervals (CIs) were calculated for model 1 (maternal hypertension and birth weight z score) and model 2 (variables in model 1, antenatal steroids, and mode of birth). Models were fitted with generalizing estimating equations and random effects modeling to account for clustering.RESULTS: A total of 6079 triplets of 24 to 32 weeks' gestation or 500 to 1499 g birth weight and 18 232 matched singletons were included. There was no difference in the primary outcome between triplets and singletons (23.4% vs 24.0%, adjusted odds ratio: 0.91, 95% CI: 0.83-1.01 for model 1 and 1.00, 95% CI: 0.90-1.11 for model 2). Rates of severe neonatal morbidities did not differ significantly between triplets and singletons. The results were also similar for a subsample of the cohort (1648 triplets and 4944 matched singletons) born at 24 to 28 weeks' gestation.CONCLUSIONS: No significant differences were identified in mortality or major neonatal morbidities between triplets who were very low birth weight or very preterm and matched singletons.
