A1 Refereed original research article in a scientific journal
Uptake of 2-fluoro-2-deoxy-D-[U-14C]-glucose during chemotherapy in murine Lewis lung tumor
Authors: Minn H, Kangas L, Kellokumpu-Lehtinen P, Klemi P, Sipilä H, Vuorinen J, Härkönen P, Lähde M
Publication year: 1992
Journal: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
Journal name in source: International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology
Journal acronym: Int J Rad Appl Instrum B
Volume: 19
Issue: 1
First page : 55
Last page: 63
ISSN: 0883-2897
Abstract
Mice bearing intramuscular Lewis lung tumor were treated with BCNU and doxorubicin (ADM) to study chemotherapy-induced changes in the uptake of 2-fluoro-2-deoxy-[U-14C]glucose (FDG). A decreased FDG uptake, tumor regression and a diminished proportion of aneuploid versus diploid cells as evaluated by DNA flow cytometry were seen after treatment with BCNU but not with ADM; HPLC indicated that most of the 14C activity in tumors was from FDG6-phosphate. The results suggest that changes in FDG uptake reflect the effectiveness of antitumor therapy. FDG may be valuable in follow-up studies of cancer treatment.
Mice bearing intramuscular Lewis lung tumor were treated with BCNU and doxorubicin (ADM) to study chemotherapy-induced changes in the uptake of 2-fluoro-2-deoxy-[U-14C]glucose (FDG). A decreased FDG uptake, tumor regression and a diminished proportion of aneuploid versus diploid cells as evaluated by DNA flow cytometry were seen after treatment with BCNU but not with ADM; HPLC indicated that most of the 14C activity in tumors was from FDG6-phosphate. The results suggest that changes in FDG uptake reflect the effectiveness of antitumor therapy. FDG may be valuable in follow-up studies of cancer treatment.
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