A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells
Tekijät: Junttila TT, Sundvall M, Lundin M, Lundin J, Tanner M, Härkönen P, Joensuu H, Isola J, Elenius K
Julkaisuvuosi: 2005
Journal: Cancer Research
Tietokannassa oleva lehden nimi: Cancer research
Lehden akronyymi: Cancer Res
Vuosikerta: 65
Numero: 4
Aloitussivu: 1384
Lopetussivu: 93
Sivujen määrä: 10
ISSN: 0008-5472
DOI: https://doi.org/10.1158/0008-5472.CAN-04-3150
Tiivistelmä
ErbB1 and ErbB2 receptors are well-characterized targets for anticancer drugs, but the clinical relevance of the related ErbB4 receptor is unknown. Here, we have assessed the clinical significance of the proteolytically cleavable ErbB4 isoforms in breast cancer patients and investigated their functions in vitro. The expression of transcripts encoding the cleavable ErbB4 isoforms associated with estrogen receptor-alpha (ER) expression (P < 0.001) and a high histologic grade of differentiation (P
ErbB1 and ErbB2 receptors are well-characterized targets for anticancer drugs, but the clinical relevance of the related ErbB4 receptor is unknown. Here, we have assessed the clinical significance of the proteolytically cleavable ErbB4 isoforms in breast cancer patients and investigated their functions in vitro. The expression of transcripts encoding the cleavable ErbB4 isoforms associated with estrogen receptor-alpha (ER) expression (P < 0.001) and a high histologic grade of differentiation (P
Turun yliopiston Tutkimustietojärjestelmän portaali