A1 Refereed original research article in a scientific journal

68Ga-chloride PET reveals human pancreatic adenocarcinoma xenografts in rats--comparison with FDG



Authors: Ujula T, Salomäki S, Autio A, Luoto P, Tolvanen T, Lehikoinen P, Viljanen T, Sipilä H, Härkönen P, Roivainen A

Publication year: 2010

Journal: Molecular Imaging and Biology

Journal name in source: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging

Journal acronym: Mol Imaging Biol

Volume: 12

Issue: 3

First page : 259

Last page: 68

Number of pages: 10

ISSN: 1536-1632

eISSN: 1860-2002

DOI: https://doi.org/10.1007/s11307-009-0267-3


Abstract
The aim of the study was to compare (68)Ga-chloride with 2-[(18)F]fluoro-2-deoxy-D: -glucose (FDG) for the imaging of pancreatic xenografts.\nRats with subcutaneous human pancreatic adenocarcinoma xenografts were evaluated in vivo by dynamic positron emission tomography (PET) and ex vivo by measuring radioactivity of excised tissues and by digital autoradiography of tumor cryosections.\nBoth tracers were capable of delineating all subcutaneous tumors from surrounding tissues by PET. The standardized uptake values of tumors by PET were 0.9 +/- 0.3 (mean +/- SD) for (68)Ga-chloride (n = 13) and 1.8 +/- 1.2 for FDG (n = 11). Ex vivo studies showed tumor-to-muscle ratio of 4.0 +/- 0.3 for (68)Ga-chloride (n = 4) and 7.9 +/- 3.2 for FDG (n = 4).\n(68)Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG. Further studies to clarify the value of (68)Ga-chloride for PET imaging of tumors are warranted.\nPURPOSE\nPROCEDURES\nRESULTS\nCONCLUSIONS



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