A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä

The role of retinoblastoma protein family in the control of germ cell proliferation, differentiation and survival




TekijätToppari J, Suominenf JS, Yan W

Julkaisuvuosi2003

JournalAPMIS

Tietokannassa oleva lehden nimiAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica

Lehden akronyymiAPMIS

Vuosikerta111

Numero1

Aloitussivu245

Lopetussivu51; discussion 251

Sivujen määrä7

ISSN0903-4641

DOIhttps://doi.org/10.1034/j.1600-0463.2003.11101281.x


Tiivistelmä
Retinoblastoma family proteins pRb, p107 and p130 are differentially expressed in the rat testis. They function in specific cell types during testicular development and spermatogenesis, participating in the control of proliferation, differentiation, and survival. Their expression levels and phosphorylation status are modulated during germ cell cycle progression and apoptosis. Hyperphosphorylated states and elevated levels of p107 are correlated with cell cycle progression, whereas hypophosphorylated states and reduced levels are associated with suppression of proliferation and apoptosis in germ cells and Leydig cells. These proteins may also serve as markers of cell cycle status of germ cells during spermatogenesis.



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