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Localization of activin receptor (ActR-IIB2) mRNA in the rat seminiferous epithelium
Tekijät: Kaipia A, Parvinen M, Toppari J
Julkaisuvuosi: 1993
Journal: Endocrinology
Tietokannassa oleva lehden nimi: Endocrinology
Lehden akronyymi: Endocrinology
Vuosikerta: 132
Numero: 1
Aloitussivu: 477
Lopetussivu: 9
ISSN: 0013-7227
DOI: https://doi.org/10.1210/endo.132.1.8380387
Tiivistelmä
In situ hybridization was used to localize the mRNA expression of the high affinity activin receptor (ActR-IIB2) in the rat seminiferous epithelium. ActR-IIB2 mRNA was expressed maximally in stages IX-XI of the seminiferous epithelial cycle. The mRNA signal was detected basally in the epithelium in type A1 and A2 spermatogonia and in Sertoli cells. In the pubertal rat testis the expression was localized in Sertoli cells around primary spermatocytes and around meiotically dividing cells. The localization of ActR-IIB2 mRNA in spermatogonia lends support to the hypothesis that activin is a spermatogonial growth factor. The expression of activin receptor mRNA in pubertal rat testis suggests that activin may have a function during meiotic maturation.
In situ hybridization was used to localize the mRNA expression of the high affinity activin receptor (ActR-IIB2) in the rat seminiferous epithelium. ActR-IIB2 mRNA was expressed maximally in stages IX-XI of the seminiferous epithelial cycle. The mRNA signal was detected basally in the epithelium in type A1 and A2 spermatogonia and in Sertoli cells. In the pubertal rat testis the expression was localized in Sertoli cells around primary spermatocytes and around meiotically dividing cells. The localization of ActR-IIB2 mRNA in spermatogonia lends support to the hypothesis that activin is a spermatogonial growth factor. The expression of activin receptor mRNA in pubertal rat testis suggests that activin may have a function during meiotic maturation.
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