A1 Refereed original research article in a scientific journal

Expression of inhibin alpha, beta A and beta B messenger ribonucleic acids in the normal human ovary and in polycystic ovarian syndrome




AuthorsJaatinen TA, Penttilä TL, Kaipia A, Ekfors T, Parvinen M, Toppari J

Publication year1994

JournalJournal of Endocrinology

Journal name in sourceThe Journal of endocrinology

Journal acronymJ Endocrinol

Volume143

Issue1

First page 127

Last page37

Number of pages11

ISSN0022-0795

DOIhttps://doi.org/10.1677/joe.0.1430127(external)


Abstract
We studied the cellular distribution of inhibin alpha, beta A and beta B mRNAs in the normal human ovary and in polycystic ovarian syndrome (PCOS) by in situ hybridization. Our results show that human granulosa cells express inhibin alpha, beta A and beta B subunit mRNAs, and theca cells express inhibin alpha and beta A subunit mRNAs. The co-localization of alpha and beta A mRNAs in theca cells supports the hypothesis that inhibin also has an autocrine function in these cells. We did not detect any inhibin subunit mRNA in the granulosa cells of atretic follicles, while theca cells also expressed alpha subunit mRNA in those follicles. The present findings suggest that the expression of inhibin subunits is regulated differently in human follicular granulosa and theca cells. It has been speculated that inhibin may be involved in the development of PCOS. Our results show that the cellular localization of inhibin subunit mRNAs is not disturbed in PCOS ovaries.



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