A1 Refereed original research article in a scientific journal

CaMKIV/Gr is dispensable for spermatogenesis and CREM-regulated transcription in male germ cells



Authors: Blaeser F, Toppari J, Heikinheimo M, Yan W, Wallace M, Ho N, Chatila TA

Publication year: 2001

Journal: American Journal of Physiology : Endocrinology and Metabolism

Journal name in source: American journal of physiology. Endocrinology and metabolism

Journal acronym: Am J Physiol Endocrinol Metab

Volume: 281

Issue: 5

First page : E931

Last page: 7

ISSN: 0193-1849

DOI: https://doi.org/10.1152/ajpendo.2001.281.5.E931


Abstract
The calcium/calmodulin-dependent protein kinase type IV/Gr (CaMKIV/Gr) is expressed in male germ cells and spermatids and has been implicated in controlling the differentiation of germ cells into mature spermatozoa. The function of CaMKIV/Gr in spermatogenesis was investigated using CaMKIV/Gr-deficient mice generated by targeted gene disruption. CaMKIV/Gr-deficient males exhibited normal spermatogenesis, and their fertility was similar to that of wild-type littermates. Notwithstanding the function of CaMKIV/Gr as an activator of cAMP response element (CRE)-dependent transcription, mRNA levels of several testis-specific CRE modulator (CREM)-regulated genes were unaltered. These results indicate that CaMKIV/Gr is not essential for spermatogenesis or for CRE-regulated gene transcription in the testis.



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