A1 Refereed original research article in a scientific journal
Genome-wide scan for linkage in Finnish hereditary prostate cancer (HPC) families identifies novel susceptibility loci at 11q14 and 3p25-26
Authors: Schleutker J, Baffoe-Bonnie AB, Gillanders E, Kainu T, Jones MP, Freas-Lutz D, Markey C, Gildea D, Riedesel E, Albertus J, Gibbs KD, Matikainen M, Koivisto PA, Tammela T, Bailey-Wilson JE, Trent JM, Kallioniemi OP, Kallioniemi OP
Publisher: WILEY-LISS
Publication year: 2003
Journal: Prostate
Journal name in source: PROSTATE
Journal acronym: PROSTATE
Volume: 57
Issue: 4
First page : 280
Last page: 289
Number of pages: 10
ISSN: 0270-4137
DOI: https://doi.org/10.1002/pros.10302
Abstract
BACKGROUND. In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.METHODS. Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.RESULTS. The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (0 = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25-26, with a two-point LOD score of 2.57 (theta = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).CONCLUSIONS. The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.
BACKGROUND. In order to identify predisposition loci to hereditary prostate cancer (HPC), we performed a genome-wide linkage analysis using samples from a genetically homogeneous population, with 13 Finnish multiplex prostate cancer families.METHODS. Altogether 87 DNA samples were genotyped from 13 families. Logarithm-of-odds (LOD) scores were calculated for all autosomes using FASTLINK and GENEHUNTER designating all unaffected men and all women as unknown.RESULTS. The highest LOD scores in the affected-only analyses were found at 11q14, where the two-point LOD score was 2.97 (0 = 0.0 at D11S901), GENEHUNTER heterogeneity LOD (HLOD) of 3.36, and a non-parametric-linkage (NPL) score of 2.67 (P = 0.008). A second positive site was at 3p25-26, with a two-point LOD score of 2.57 (theta = 0.01 at D3S1297), HLOD of 2.15, and NPL score of 2.27 (P = 0.02).CONCLUSIONS. The results suggest two HPC regions in the Finnish population, which have not been reported previously and warrant further study.
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