A procedure for the preparation and isolation of nucleoside-5 '-diphosphates
: Heidi J. Korhonen, Hannah L. Bolt, David R. W. Hodgson
Publisher: BEILSTEIN-INSTITUT
: 2015
: Beilstein Journal of Organic Chemistry
: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
: BEILSTEIN J ORG CHEM
: 11
: 469
: 472
: 4
: 1860-5397
DOI: https://doi.org/10.3762/bjoc.11.52(external)
Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the S(N)2 displacements of the tosylate ion from 5'-tosylnucleosides to afford nucleoside-5'-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5'-diphosphates from crude reaction mixtures.