A procedure for the preparation and isolation of nucleoside-5 '-diphosphates




Heidi J. Korhonen, Hannah L. Bolt, David R. W. Hodgson

PublisherBEILSTEIN-INSTITUT

2015

Beilstein Journal of Organic Chemistry

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

BEILSTEIN J ORG CHEM

11

469

472

4

1860-5397

DOIhttps://doi.org/10.3762/bjoc.11.52(external)



Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the S(N)2 displacements of the tosylate ion from 5'-tosylnucleosides to afford nucleoside-5'-diphosphates. Selective precipitation permitted the direct isolation of nucleoside-5'-diphosphates from crude reaction mixtures.




Last updated on 2024-26-11 at 17:47