A1 Refereed original research article in a scientific journal

Does reduced erythrocyte C3b receptor (CR1) activity contribute to the pathogenesis of yersinia triggered reactive arthritis?




AuthorsLahesmaa R, Eerola E, Toivanen A

Publication year1992

JournalAnnals of the Rheumatic Diseases

Journal name in sourceAnnals of the rheumatic diseases

Journal acronymAnn Rheum Dis

Volume51

Issue1

First page 97

Last page100

Number of pages4

ISSN0003-4967

DOIhttps://doi.org/10.1136/ard.51.1.97(external)


Abstract
Erythrocyte C3b receptor (CR1) activity was measured in 27 patients with yersinia triggered reactive arthritis and in 151 control subjects, including 36 patients with uncomplicated yersiniosis and 115 healthy subjects. CR1 was measured by the immune adherence haemagglutination method. Patients with yersinia triggered reactive arthritis had reduced levels of CR1 compared with the controls. This difference was mainly due to the finding that five out of six HLA B27 negative patients with arthritis had decreased CR1 activity. Such a quantitative difference may contribute to the pathogenesis of reactive arthritis by affecting the clearance of immune complexes.



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