A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Carboplatin and etoposide in extensive small cell lung cancer
Tekijät: Viren M, Liippo K, Ojala A, Helle L, Hinkka S, Huovinen R, Jakobsson M, Järvinen M, Paloheimo S, Salmi R
Julkaisuvuosi: 1994
Journal: Acta Oncologica
Tietokannassa oleva lehden nimi: Acta oncologica (Stockholm, Sweden)
Lehden akronyymi: Acta Oncol
Vuosikerta: 33
Numero: 8
Aloitussivu: 921
Lopetussivu: 4
Sivujen määrä: 4
ISSN: 0284-186X
DOI: https://doi.org/10.3109/02841869409098457
Tiivistelmä
The combination of carboplatin and etoposide was evaluated in 61 previously untreated patients with extensive small cell lung cancer. Treatment was given at four-week intervals with 450 mg/m2 of carboplatin intravenously (i.v.) on day 1 and etoposide 100 mg/m2 i.v. on days 1-3. The response was complete in 5 (9%) and partial in 28 (50%) of the 56 evaluable patients (overall response rate 59%). The median time to progression after response as well as the median survival time in all evaluable patients was 4.6 months. WHO grade 3 and 4 leukopenia and thrombocytopenia occurred in 8% and 11% of the courses respectively. Two treatment-related deaths were registered. The combination of carboplatin and etoposide used in the present study produced acceptable response rate and toxicity, but duration of response and median survival were shorter than expected from earlier studies.
The combination of carboplatin and etoposide was evaluated in 61 previously untreated patients with extensive small cell lung cancer. Treatment was given at four-week intervals with 450 mg/m2 of carboplatin intravenously (i.v.) on day 1 and etoposide 100 mg/m2 i.v. on days 1-3. The response was complete in 5 (9%) and partial in 28 (50%) of the 56 evaluable patients (overall response rate 59%). The median time to progression after response as well as the median survival time in all evaluable patients was 4.6 months. WHO grade 3 and 4 leukopenia and thrombocytopenia occurred in 8% and 11% of the courses respectively. Two treatment-related deaths were registered. The combination of carboplatin and etoposide used in the present study produced acceptable response rate and toxicity, but duration of response and median survival were shorter than expected from earlier studies.
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