A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Renal carnitine concentration decreases in endotoxic dogs
Tekijät: Gullichsen E, Heinonen OJ, Nelimarkka O, Kuttila K, Niinikoski J
Julkaisuvuosi: 1991
Journal: Critical Care Medicine
Tietokannassa oleva lehden nimi: Critical care medicine
Lehden akronyymi: Crit Care Med
Vuosikerta: 19
Numero: 6
Aloitussivu: 792
Lopetussivu: 5
Sivujen määrä: 4
ISSN: 0090-3493
DOI: https://doi.org/10.1097/00003246-199106000-00011
Tiivistelmä
Renal cortical and serum carnitine concentrations were studied in seven anesthetized beagle dogs in which acute circulatory collapse was induced by an iv injection of Escherichia coli endotoxin, 0.5 mg/kg given over 15 mins. Four controls received normal saline.\nThe endotoxin injection resulted in cardiac depression, renal hypoperfusion, acidosis with a decrease in urinary output, and hematuria. Arterial and renal venous free carnitine concentrations increased significantly in endotoxemia during the 5-hr experiment, but remained low and unchanged in the controls. Circulating acyl-carnitine concentrations underwent no essential changes in either group. Total, free, and acyl-carnitine concentrations decreased in endotoxic renal tissue.\nThese data suggest that endotoxemia decreases carnitine concentrations in the renal cortex, but increases free carnitine concentrations in the circulation.\nBACKGROUND AND METHODS\nRESULTS\nCONCLUSIONS
Renal cortical and serum carnitine concentrations were studied in seven anesthetized beagle dogs in which acute circulatory collapse was induced by an iv injection of Escherichia coli endotoxin, 0.5 mg/kg given over 15 mins. Four controls received normal saline.\nThe endotoxin injection resulted in cardiac depression, renal hypoperfusion, acidosis with a decrease in urinary output, and hematuria. Arterial and renal venous free carnitine concentrations increased significantly in endotoxemia during the 5-hr experiment, but remained low and unchanged in the controls. Circulating acyl-carnitine concentrations underwent no essential changes in either group. Total, free, and acyl-carnitine concentrations decreased in endotoxic renal tissue.\nThese data suggest that endotoxemia decreases carnitine concentrations in the renal cortex, but increases free carnitine concentrations in the circulation.\nBACKGROUND AND METHODS\nRESULTS\nCONCLUSIONS
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