A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Rapid selection of complement-inhibiting protein variants in group A Streptococcus epidemic waves
Tekijät: Hoe NP, Nakashima K, Lukomski S, Grigsby D, Liu M, Kordari P, Dou SJ, Pan X, Vuopio-Varkila J, Salmelinna S, McGeer A, Low DE, Schwartz B, Schuchat A, Naidich S, Fu YX, De Lorenzo D, Musser JM
Julkaisuvuosi: 1999
Journal: Nature Medicine
Tietokannassa oleva lehden nimi: Nature medicine
Lehden akronyymi: Nat Med
Vuosikerta: 5
Numero: 8
Aloitussivu: 924
Lopetussivu: 9
Sivujen määrä: 6
ISSN: 1078-8956
DOI: https://doi.org/10.1038/11369
Tiivistelmä
Serotype M1 group A Streptococcus strains cause epidemic waves of human infections long thought to be mono- or pauciclonal. The gene encoding an extracellular group A Streptococcus protein (streptococcal inhibitor of complement) that inhibits human complement was sequenced in 1,132 M1 strains recovered from population-based surveillance of infections in Canada, Finland and the United States. Epidemic waves are composed of strains expressing a remarkably heterogeneous array of variants of streptococcal inhibitor of complement that arise very rapidly by natural selection on mucosal surfaces. Thus, our results enhance the understanding of pathogen population dynamics in epidemic waves and infectious disease reemergence.
Serotype M1 group A Streptococcus strains cause epidemic waves of human infections long thought to be mono- or pauciclonal. The gene encoding an extracellular group A Streptococcus protein (streptococcal inhibitor of complement) that inhibits human complement was sequenced in 1,132 M1 strains recovered from population-based surveillance of infections in Canada, Finland and the United States. Epidemic waves are composed of strains expressing a remarkably heterogeneous array of variants of streptococcal inhibitor of complement that arise very rapidly by natural selection on mucosal surfaces. Thus, our results enhance the understanding of pathogen population dynamics in epidemic waves and infectious disease reemergence.
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