A1 Refereed original research article in a scientific journal
Epidemiological typing of Candida albicans from bloodstream infections by restriction enzyme analysis
Authors: Poikonen E, Vuopio-Varkila J, Kaukoranta-Tolvanen SS, Sivonen A, Siren E, Ruutu P
Publication year: 2001
Journal: Scandinavian Journal of Infectious Diseases
Journal name in source: Scandinavian journal of infectious diseases
Journal acronym: Scand J Infect Dis
Volume: 33
Issue: 2
First page : 140
Last page: 4
Number of pages: 5
ISSN: 0036-5548
Abstract
Candida albicans blood culture isolates (n = 142) from 130 patients treated in 7 acute care hospitals in Southern Finland between 1986 and 1995 were typed by restriction enzyme analysis (REA) with EcoRI and MspI. REA revealed 118 distinct DNA types: 13 were detected in > 1 patient and 105 DNA types were unique. Patients with identical DNA types were not temporally or geographically clustered. Among 11 patients with more than 1 C. albicans isolate during 1 episode of fungemia the DNA type remained the same, except in 1 patient. These results indicate that REA is a powerful tool for the epidemiological typing of C. albicans infections.
Candida albicans blood culture isolates (n = 142) from 130 patients treated in 7 acute care hospitals in Southern Finland between 1986 and 1995 were typed by restriction enzyme analysis (REA) with EcoRI and MspI. REA revealed 118 distinct DNA types: 13 were detected in > 1 patient and 105 DNA types were unique. Patients with identical DNA types were not temporally or geographically clustered. Among 11 patients with more than 1 C. albicans isolate during 1 episode of fungemia the DNA type remained the same, except in 1 patient. These results indicate that REA is a powerful tool for the epidemiological typing of C. albicans infections.
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