A1 Refereed original research article in a scientific journal
Downregulation of mafB expression in T-helper cells during early differentiation in vitro
Authors: Hashizume H, Hamalainen H, Sun Q, Sucharczuk A, Lahesmaa R
Publisher: WILEY
Publication year: 2003
Journal: Scandinavian Journal of Immunology
Journal name in source: SCANDINAVIAN JOURNAL OF IMMUNOLOGY
Journal acronym: SCAND J IMMUNOL
Volume: 57
Issue: 1
First page : 28
Last page: 34
Number of pages: 7
ISSN: 0300-9475
DOI: https://doi.org/10.1046/j.1365-3083.2003.01181.x
Abstract
We have studied the expression of a human homologue of mafB (maf -1), a member of the family of large maf transcription factors. In support of the suggested key role that mafB expression plays in differentiating macrophages, we found mafB to be expressed at a very high level in monocytic U937 and THP-1 cell lines. However, we show here that mafB transcription is not restricted to myeloid cells but can also be detected in lymphoid cells, indicating transcriptional plasticity during haematopoiesis. In conclusion, strong proliferative signals mediated by T-cell activation and interleukins (IL-4 and IL-12) downregulate the mafB messenger RNA transcript level when resting naive CD4(+) T-helper cells enter the differentiation pathway in vitro .
We have studied the expression of a human homologue of mafB (maf -1), a member of the family of large maf transcription factors. In support of the suggested key role that mafB expression plays in differentiating macrophages, we found mafB to be expressed at a very high level in monocytic U937 and THP-1 cell lines. However, we show here that mafB transcription is not restricted to myeloid cells but can also be detected in lymphoid cells, indicating transcriptional plasticity during haematopoiesis. In conclusion, strong proliferative signals mediated by T-cell activation and interleukins (IL-4 and IL-12) downregulate the mafB messenger RNA transcript level when resting naive CD4(+) T-helper cells enter the differentiation pathway in vitro .
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