A1 Refereed original research article in a scientific journal
Postpartum-activation of multiple sclerosis is associated with down-regulation of tolerogenic HLA-G
Authors: Airas L, Nikula T, Huang YH, Lahesmaa R, Wiendl H
Publisher: ELSEVIER SCIENCE BV
Publication year: 2007
Journal: Journal of Neuroimmunology
Journal name in source: JOURNAL OF NEUROIMMUNOLOGY
Journal acronym: J NEUROIMMUNOL
Volume: 187
Issue: 1-2
First page : 205
Last page: 211
Number of pages: 7
ISSN: 0165-5728
DOI: https://doi.org/10.1016/j.jneuroim.2007.05.008
Abstract
We used microarray analysis to obtain insights into the immuno-regulatory mechanisms controlling pregnancy-associated MS disease activity. We studied expression levels of 5000 immune-related genes in peripheral blood mononuclear cells in patients with relapsing-remitting MS during pregnancy and postpartum and in comparison to controls. In the microarray analysis, HLA-G, a non-classical major histocornpatibility molecule mainly attributed with immune-tolerogenic functions, was found differentially regulated between MS patients and controls. The finding was corroborated and extended by real-time PCR, flow-cytometry and ELISA in a larger patient sample. The results delineate an important role for the immune-tolerogenic molecule HLA-G in modulating disease activity and pregnancy-related changes in MS patients. (c) 2007 Elsevier B.V. All rights reserved.
We used microarray analysis to obtain insights into the immuno-regulatory mechanisms controlling pregnancy-associated MS disease activity. We studied expression levels of 5000 immune-related genes in peripheral blood mononuclear cells in patients with relapsing-remitting MS during pregnancy and postpartum and in comparison to controls. In the microarray analysis, HLA-G, a non-classical major histocornpatibility molecule mainly attributed with immune-tolerogenic functions, was found differentially regulated between MS patients and controls. The finding was corroborated and extended by real-time PCR, flow-cytometry and ELISA in a larger patient sample. The results delineate an important role for the immune-tolerogenic molecule HLA-G in modulating disease activity and pregnancy-related changes in MS patients. (c) 2007 Elsevier B.V. All rights reserved.
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