Chlamydia pneumoniae infection in IL-10 knock out mice: Accelerated clearance but severe pulmonary inflammatory response



: Penttila T, Haveri A, Tammiruusu A, Vuola JM, Lahesmaa R, Puolakkainen M

Publisher: ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD

: 2008

: Microbial Pathogenesis

: MICROBIAL PATHOGENESIS

: MICROB PATHOGENESIS

: 45

: 1

: 25

: 29

: 5

: 0882-4010

DOI: https://doi.org/10.1016/j.micpath.2008.02.004


In interleukin-10 knock out (IL-10 KO) mice, accelerated clearance of pulmonary Chlamydia pneumoniae infection was observed. On the other hand, the histopathological changes in lung tissue were more pronounced in IL-10 KO mice at all time points after infection and repeated infection than in the wild type mice. Both ex vivo induced antigen-specific proliferation as well as production of proinflammatory cytokines by splenocytes were higher in IL-10 KO mice than in WT mice. Also, intrapulmonary proinflammatory cytokine levels were higher in IL-10 KO mice than in the WT mice, The lack of anti-inflammatory action of IL-10 is likely to contribute to the enhanced clearance but severe inflammation in this experimental model. (c) 2008 Elsevier Ltd. All rights reserved.



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