Eurostat activities in the domain of health status and health determinants are currently covered by surveys; however, one core activity is missing: the regular collection of diagnosis-specific morbidity data with incidence and prevalence rates. A legal basis for such data collection is provided by Regulation No 1338/2008 establishing a framework for Community statistics on public health and health and safety at work. That regulation foresees an implementation of morbidity statistics at EU level. Eurostat’s commitment in developing the conceptual and methodological framework for establishing such data collection on morbidity has a long-standing tradition; however, this ambitious goal has not yet been achieved. The reason behind is that from a methodological and operational point of view, establishing morbidity statistics is an extremely complex exercise, in particular with regards to comparability of data across countries. To guide the MS in the piloting phase, detailed guidelines were produced by the Morbidity Statistics Development Group in 2007: for each entry in the recommended shortlist the appropriate measures on incidence and/or prevalence for data delivery were indicated. Each country had to find appropriate sources for producing best national estimates. The main criteria for the inclusion of a data source was statistical robustness on the main data quality parameters and hence permit reliable inter country comparisons. Hence, like many Eurostat statistics, the compilation of diagnosis-specific morbidity statistics is output driven and not source oriented. Altogether 16 MS participated at pilot studies on diagnosis-specific morbidity statistic from 2005 to 2011. In 2011, Eurostat established the Task Force on Morbidity Statistics (TF MORB) for analysing the pilots’ results, especially in view of sources and best estimates. TF MORB is presenting this report with an indepth analysis of the pilot studies and methodological recommendations for paving the way ahead to overcome the pioneering stage. The establishment of diagnosis-based morbidity statistics will be crucial for filling an information gap on the health status of the EU population which has severely hampered the development of public health indicators at EU level. The draft of this report has been presented and discussed at the Technical Group on Morbidity in June 2013; the final version has been presented at the Working Group on Public Health Statistics (WGPH) in December 2013 which endorsed it