A1 Refereed original research article in a scientific journal
The role of respiratory viruses in otitis media
Authors: Heikkinen T
Publisher: ELSEVIER SCI LTD
Publication year: 2000
Journal: Vaccine
Journal name in source: VACCINE
Journal acronym: VACCINE
Volume: 19
First page : S51
Last page: S55
Number of pages: 5
ISSN: 0264-410X
DOI: https://doi.org/10.1016/S0264-410X(00)00278-4
Abstract
Evidence derived from numerous studies ranging from animal experiments to extensive clinical trials supports a crucial role for respiratory viruses in acute otitis media. Viral infection of the upper respiratory tract initiates the whole cascade of events that ultimately leads to development of acute otitis media, and viruses contribute to the pathogenesis of this disease by several mechanisms. Recent data indicate that at least some types of viruses actively invade the middle ear and may also interfere with the outcome of otitis media. The availability of effective vaccines against the principal viruses predisposing to acute otitis media could be expected to result in a substantial reduction in the incidence of this disease. (C) 2000 Elsevier Science Ltd. All rights reserved.
Evidence derived from numerous studies ranging from animal experiments to extensive clinical trials supports a crucial role for respiratory viruses in acute otitis media. Viral infection of the upper respiratory tract initiates the whole cascade of events that ultimately leads to development of acute otitis media, and viruses contribute to the pathogenesis of this disease by several mechanisms. Recent data indicate that at least some types of viruses actively invade the middle ear and may also interfere with the outcome of otitis media. The availability of effective vaccines against the principal viruses predisposing to acute otitis media could be expected to result in a substantial reduction in the incidence of this disease. (C) 2000 Elsevier Science Ltd. All rights reserved.
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