A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
INFLUENZA VACCINATION IN THE PREVENTION OF ACUTE OTITIS-MEDIA IN CHILDREN
Tekijät: HEIKKINEN T, RUUSKANEN O, WARIS M, ZIEGLER T, AROLA M, HALONEN P
Kustantaja: AMER MEDICAL ASSOC
Julkaisuvuosi: 1991
Journal: AMERICAN JOURNAL OF DISEASES OF CHILDREN
Tietokannassa oleva lehden nimi: AMERICAN JOURNAL OF DISEASES OF CHILDREN
Lehden akronyymi: AM J DIS CHILD
Vuosikerta: 145
Numero: 4
Aloitussivu: 445
Lopetussivu: 448
Sivujen määrä: 4
ISSN: 0096-8994
DOI: https://doi.org/10.1001/archpedi.1991.02160040103017
Tiivistelmä
We studied a new approach to the prevention of acute otitis media through the administration of influenza vaccine to 187 day-care center children aged 1 to 3 years before the influenza A epidemic of 1988-1989. The control group consisted of 187 unvaccinated children of similar age and background. During the 6-week study period, influenza A infection was diagnosed in five (3%) of 187 vaccinees and in 29 (16%) of 187 controls. Acute otitis media developed in three (60%) of five vaccinees with an influenza A infection compared with 18 (67%) of 27 controls (excluded were two children with a double viral infection). The incidence of acute otitis media associated with influenza A was reduced by 83% in the vaccinees. The total number of children with acute otitis media in the vaccine group was 35, compared with 55 in the control group, disclosing a 36% reduction among the vaccinees. We conclude that influenza vaccination decreases the incidence of acute otitis media in children during an influenza A epidemic, suggesting also that other vaccines against respiratory viruses may be an effective way to reduce the incidence of acute otitis media.
We studied a new approach to the prevention of acute otitis media through the administration of influenza vaccine to 187 day-care center children aged 1 to 3 years before the influenza A epidemic of 1988-1989. The control group consisted of 187 unvaccinated children of similar age and background. During the 6-week study period, influenza A infection was diagnosed in five (3%) of 187 vaccinees and in 29 (16%) of 187 controls. Acute otitis media developed in three (60%) of five vaccinees with an influenza A infection compared with 18 (67%) of 27 controls (excluded were two children with a double viral infection). The incidence of acute otitis media associated with influenza A was reduced by 83% in the vaccinees. The total number of children with acute otitis media in the vaccine group was 35, compared with 55 in the control group, disclosing a 36% reduction among the vaccinees. We conclude that influenza vaccination decreases the incidence of acute otitis media in children during an influenza A epidemic, suggesting also that other vaccines against respiratory viruses may be an effective way to reduce the incidence of acute otitis media.
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