A1 Refereed original research article in a scientific journal

Organocatalytic Asymmetric Synthesis of 2,3 '-Connected Bis-Indolinones by Mannich Reactions of N-Acetylindolin-3-ones with Isatin N-Boc Ketimines



Authors: Gajulapalli VPR, Jafari E, Kundu DS, Mahajan S, Peuronen A, Rissanen K, Enders D

Publisher: GEORG THIEME VERLAG KG

Publication year: 2017

Journal: Synthesis: stuttgart

Journal name in source: SYNTHESIS-STUTTGART

Journal acronym: SYNTHESIS-STUTTGART

Volume: 49

Issue: 22

First page : 4986

Last page: 4995

Number of pages: 10

ISSN: 0039-7881

DOI: https://doi.org/10.1055/s-0036-1590823


Abstract
A highly diastereo- and enantioselective Mannich reaction of N-acetylindolin-3-ones with isatin N-Boc ketimines to form 2,3'-connected bis-indolinones is developed employing a low loading of a readily available bifunctional thiourea catalyst. The asymmetric synthesis connects two indolinones via a vic-diamine unit and generates two neighboring stereocenters.



Last updated on 2024-26-11 at 15:11