A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
N-Heterocyclic Carbene-Catalyzed Activation of -Chloroaldehydes: Asymmetric Synthesis of 5-Cyano-Substituted Dihydropyranones
Tekijät: Li S, Chen XY, Liu Q, Peuronen A, Rissanen K, Enders D
Kustantaja: GEORG THIEME VERLAG KG
Julkaisuvuosi: 2017
Journal: Synthesis: stuttgart
Tietokannassa oleva lehden nimi: SYNTHESIS-STUTTGART
Lehden akronyymi: SYNTHESIS-STUTTGART
Vuosikerta: 49
Numero: 21
Aloitussivu: 4861
Lopetussivu: 4868
Sivujen määrä: 8
ISSN: 0039-7881
DOI: https://doi.org/10.1055/s-0036-1588509
Tiivistelmä
An N-heterocyclic carbene (NHC)-catalyzed asymmetric [4+2] annulation of (E)-2-benzoyl-3-phenylacrylonitriles with alpha-chloroaldehydes has been developed. The protocol leads to 5-cyano-substituted dihydropyranones in good to excellent yields with excellent diastereo- and enantioselectivities (up to 93% yield, >20:1 d.r. and 99% ee).
An N-heterocyclic carbene (NHC)-catalyzed asymmetric [4+2] annulation of (E)-2-benzoyl-3-phenylacrylonitriles with alpha-chloroaldehydes has been developed. The protocol leads to 5-cyano-substituted dihydropyranones in good to excellent yields with excellent diastereo- and enantioselectivities (up to 93% yield, >20:1 d.r. and 99% ee).
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