A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Asymmetric Synthesis of Five-Membered Spiropyrazolones via N-Heterocyclic Carbene (NHC)-Catalyzed [3+2] Annulations
Tekijät: Li S, Wang L, Chauhan P, Peuronen A, Rissanen K, Enders D
Kustantaja: GEORG THIEME VERLAG KG
Julkaisuvuosi: 2017
Journal: Synthesis: stuttgart
Tietokannassa oleva lehden nimi: SYNTHESIS-STUTTGART
Lehden akronyymi: SYNTHESIS-STUTTGART
Vuosikerta: 49
Numero: 8
Aloitussivu: 1808
Lopetussivu: 1815
Sivujen määrä: 8
ISSN: 0039-7881
DOI: https://doi.org/10.1055/s-0036-1588381
Tiivistelmä
A new synthetic strategy for the asymmetric synthesis of five-membered spiropyrazolones via N-heterocyclic carbene-catalyzed [3+2] annulations employing enals and unsaturated pyrazolones as substrates has been developed. The new protocol allows the flexible variation of all four substituents of the pharmaceutically important spiropyrazolones in moderate to very good yields and in most cases with excellent diastereoselectivities and good to excellent enantioselectivities.
A new synthetic strategy for the asymmetric synthesis of five-membered spiropyrazolones via N-heterocyclic carbene-catalyzed [3+2] annulations employing enals and unsaturated pyrazolones as substrates has been developed. The new protocol allows the flexible variation of all four substituents of the pharmaceutically important spiropyrazolones in moderate to very good yields and in most cases with excellent diastereoselectivities and good to excellent enantioselectivities.
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