A1 Refereed original research article in a scientific journal
Widespread decrease of nicotinic acetylcholine receptors in Parkinson's disease
Authors: Fujita M, Ichise M, Zoghbi SS, Liow JS, Ghose S, Vines DC, Sangare J, Lu JQ, Cropley VL, Iida H, Kim KM, Cohen RM, Bara-Jimenez W, Ravina B, Innis RB
Publisher: WILEY-LISS
Publication year: 2006
Journal: Annals of Neurology
Journal name in source: ANNALS OF NEUROLOGY
Journal acronym: ANN NEUROL
Volume: 59
Issue: 1
First page : 174
Last page: 177
Number of pages: 4
ISSN: 0364-5134
DOI: https://doi.org/10.1002/ana.20688
Abstract
Objective: Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. Methods: Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [I-123]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K,). Results. Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K-1. Interpretation: These results indicate the importance of extending the study to demented patients.
Objective: Nicotinic acetylcholine receptors have close interactions with the dopaminergic system and play critical roles in cognitive function. The purpose of this study was to compare these receptors between living PD patients and healthy subjects. Methods: Nicotinic acetylcholine receptors were imaged in 10 nondemented Parkinson's disease patients and 15 age-matched healthy subjects using a single-photon emission computed tomography ligand [I-123]5-iodo-3-[2(S)-2-azetidinylmethoxy]pyridine. Using an arterial input function, we measured the total distribution volume (V; specific plus nondisplaceable), as well as the delivery (K,). Results. Parkinson's disease showed a widespread significant decrease (approximately 10%) of V in both cortical and subcortical regions without a significant change in K-1. Interpretation: These results indicate the importance of extending the study to demented patients.
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