A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Use of [C-11]acetate and [O-15]O-2 PET for the assessment of myocardial oxygen utilization in patients with chronic myocardial infarction
Tekijät: Ukkonen H, Knuuti J, Katoh C, Iida H, Sipila H, Lehikoinen P, Nagren K, Voipio-Pulkki LM
Kustantaja: SPRINGER
Julkaisuvuosi: 2001
Journal: European Journal of Nuclear Medicine
Tietokannassa oleva lehden nimi: EUROPEAN JOURNAL OF NUCLEAR MEDICINE
Lehden akronyymi: EUR J NUCL MED
Vuosikerta: 28
Numero: 3
Aloitussivu: 334
Lopetussivu: 339
Sivujen määrä: 6
ISSN: 0340-6997
DOI: https://doi.org/10.1007/s002590000444
Tiivistelmä
Carbon-11 acetate positron emission tomography (PET) has been widely used to assess regional oxidative metabolism of the heart. However, the accuracy of [C-11]acetate PET in assessing oxidative metabolism in infarcted myocardium remains controversial. Thirteen patients with stable coronary artery disease and old myocardial infarction were studied. The O-15-based PET studies yielded regional blood flow (rMBF, ml/min/g) and oxygen consumption (rMMRO(2), ml/min/g), which was compared with the myocardial clearance rate constant (k(mono)) of [C-11]acetate in segments with rMBF greater than or equal to 75% (group A), 50%-74% (group B) or <50% (group C) of the normal reference segment. Mean MBF was 0.960.08 ml/g/min in group A, 0.67 +/-0.06 ml/g/min in group B and 0.42 +/-0.07 ml/g/min in group C segments. The segmental rMMRO(2) correlated linearly with k(mono) (r=0.89, P<0.001, y=0.61x+0.026). The k(mono)/rMMRO(2) ratio was comparable in the group A and B segments (0.990.19 vs 1.07 +/-0.21, P=NS). However, the ratio was significantly higher in the group C segments (1.28 +/-0.35, P=0.037). It is concluded that k(mono) of [C-11]acetate correlates linearly with rMMRO(2) determined by [O-15]O-2 inhalation. However, k(mono) appears to yield higher rMMRO(2) estimates than the [O-15]O-2 method in low-flow areas.
Carbon-11 acetate positron emission tomography (PET) has been widely used to assess regional oxidative metabolism of the heart. However, the accuracy of [C-11]acetate PET in assessing oxidative metabolism in infarcted myocardium remains controversial. Thirteen patients with stable coronary artery disease and old myocardial infarction were studied. The O-15-based PET studies yielded regional blood flow (rMBF, ml/min/g) and oxygen consumption (rMMRO(2), ml/min/g), which was compared with the myocardial clearance rate constant (k(mono)) of [C-11]acetate in segments with rMBF greater than or equal to 75% (group A), 50%-74% (group B) or <50% (group C) of the normal reference segment. Mean MBF was 0.960.08 ml/g/min in group A, 0.67 +/-0.06 ml/g/min in group B and 0.42 +/-0.07 ml/g/min in group C segments. The segmental rMMRO(2) correlated linearly with k(mono) (r=0.89, P<0.001, y=0.61x+0.026). The k(mono)/rMMRO(2) ratio was comparable in the group A and B segments (0.990.19 vs 1.07 +/-0.21, P=NS). However, the ratio was significantly higher in the group C segments (1.28 +/-0.35, P=0.037). It is concluded that k(mono) of [C-11]acetate correlates linearly with rMMRO(2) determined by [O-15]O-2 inhalation. However, k(mono) appears to yield higher rMMRO(2) estimates than the [O-15]O-2 method in low-flow areas.
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