A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä
Iterative reconstruction based on median root prior in quantification of myocardial blood flow and oxygen metabolism
Tekijät: Katoh C, Ruotsalainen U, Laine H, Alenius S, Iida H, Nuutila P, Knuuti J
Kustantaja: SOC NUCLEAR MEDICINE INC
Julkaisuvuosi: 1999
Journal: Journal of Nuclear Medicine
Tietokannassa oleva lehden nimi: JOURNAL OF NUCLEAR MEDICINE
Lehden akronyymi: J NUCL MED
Vuosikerta: 40
Numero: 5
Aloitussivu: 862
Lopetussivu: 867
Sivujen määrä: 6
ISSN: 0161-5505
Tiivistelmä
The aim of this study was to compare reproducibility and accuracy of two reconstruction methods in quantification of myocardial blood flow and oxygen metabolism with O-15-labeled tracers and PET. A new iterative Bayesian reconstruction method based on median root prior (MRP) was compared with filtered backprojection (FBP) reconstruction method, which is traditionally used for image reconstruction in PET studies. Methods: Regional myocardial blood flow (rMBF), oxygen extraction fraction (rOEF) and myocardial metabolic rate of oxygen consumption (rMMRO(2)) were quantified from images reconstructed in 27 subjects using both MRP and FBP methods. For each subject, regions of interest (ROls) were drawn on the lateral, anterior and septal regions on four planes. To test reproducibility, the ROI drawing procedure was repeated. By using two sets of ROls, variability was evaluated from images reconstructed with the MRP and the FBP methods. Results: Correlation coefficients of significantly higher in the images reconstructed with the MRP reconstruction method compared with the images reconstructed with the FBP method (rMBF: MRP r= 0.896 versus FBP r= 0.737, P< 0.001; rOEF: 0.915 versus 0.855, P < 0.001; rMMRO(2): 0.954 versus 0.885, P < 0.001). Coefficient of variation for each parameter was significantly lower in MRP Images than in FBP images (rMBF: MRP 23.5% +/- 11.3% versus FBP 30.1% +/- 14.7%, P < 0.001; rOEF: 21.0% +/- 11.1% versus 32.1% +/- 19.8%, P <0.001; rMMRO(2): 23.1% +/- 13.2% versus 30.3% +/- 19.1%, P < 0.001). Conclusion: The MRP reconstruction method provides higher reproducibility and lower variability in the quantitative myocardial parameters when compared with the FBP method. This study shows that the new MRP reconstruction method improves accuracy and stability of clinical quantification of myocardial blood flow and oxygen metabolism with O-15 and PET.
The aim of this study was to compare reproducibility and accuracy of two reconstruction methods in quantification of myocardial blood flow and oxygen metabolism with O-15-labeled tracers and PET. A new iterative Bayesian reconstruction method based on median root prior (MRP) was compared with filtered backprojection (FBP) reconstruction method, which is traditionally used for image reconstruction in PET studies. Methods: Regional myocardial blood flow (rMBF), oxygen extraction fraction (rOEF) and myocardial metabolic rate of oxygen consumption (rMMRO(2)) were quantified from images reconstructed in 27 subjects using both MRP and FBP methods. For each subject, regions of interest (ROls) were drawn on the lateral, anterior and septal regions on four planes. To test reproducibility, the ROI drawing procedure was repeated. By using two sets of ROls, variability was evaluated from images reconstructed with the MRP and the FBP methods. Results: Correlation coefficients of significantly higher in the images reconstructed with the MRP reconstruction method compared with the images reconstructed with the FBP method (rMBF: MRP r= 0.896 versus FBP r= 0.737, P< 0.001; rOEF: 0.915 versus 0.855, P < 0.001; rMMRO(2): 0.954 versus 0.885, P < 0.001). Coefficient of variation for each parameter was significantly lower in MRP Images than in FBP images (rMBF: MRP 23.5% +/- 11.3% versus FBP 30.1% +/- 14.7%, P < 0.001; rOEF: 21.0% +/- 11.1% versus 32.1% +/- 19.8%, P <0.001; rMMRO(2): 23.1% +/- 13.2% versus 30.3% +/- 19.1%, P < 0.001). Conclusion: The MRP reconstruction method provides higher reproducibility and lower variability in the quantitative myocardial parameters when compared with the FBP method. This study shows that the new MRP reconstruction method improves accuracy and stability of clinical quantification of myocardial blood flow and oxygen metabolism with O-15 and PET.
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